Functional protein
delivery. Without
cargo conjugation.

A peptide chaperone enabling retinal delivery of separately supplied proteins and other therapeutic cargo.

Scientific evidence

Demonstrated biological activity.

Published mouse ocular studies · delivery and biological activity [1]

No covalent cargo linkage

Proteins and other cargo are co-administered with Nuc1, rather than chemically attached.

Multiple cargo classes

Delivery or enhanced activity shown with proteins, antibodies, peptides, a labeled steroid and AAV.

Functional XIAP delivery

Approximately 60% fewer TUNEL-positive cells after experimental retinal detachment.

Platform application

Delivery linked to biological activity.

Nuc1 with recombinant XIAP, administered intravitreally 24 hours after experimental detachment, reduced acute retinal apoptosis. Published studies also demonstrated enhanced anti-VEGF antibody activity and decorin-associated antifibrotic activity in mouse ocular models.

Platform: Nuc1 peptide chaperone
Formulation principle: Separate cargo · no covalent conjugation
Delivery route: Intravitreal; additional ocular applications

Supporting sources

[1] Kumar and colleagues. IOVS. 2024;65(8):31. Nuc1-mediated ocular delivery. PMID: 39028980. ↗

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